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DYNC1H1

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GENERAL INFORMATION

Gene name

 DYNC1H1

Gene description

 Dynein, cytoplasmic 1, heavy chain 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & centrosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Centrosome (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB010443
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & centrosome.

Main location

 Centrosome (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB010443 A-431 Nucleus
Centrosome
Cytosol
CAB010443 U-251 MG Centrosome
Cytosol

GENE INFORMATION

Gene name

 DYNC1H1 (HGNC Symbol)

Synonyms

 CMT2O, DHC1, DNCH1, Dnchc1, DNCL, DNECL, HL-3, p22

Description

 Dynein, cytoplasmic 1, heavy chain 1 (HGNC Symbol)

Entrez gene summary

 Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]

Chromosome

 14

Cytoband

 q32.31

Chromosome location (bp)

 101964528 - 102050792

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197102 (version 83.38)

Entrez gene

 1778

UniProt

 Q14204 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14204

Antibodypedia

 DYNC1H1 antibodies

PROTEIN BROWSER
DYNC1H1-001
DYNC1H1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYNC1H1-001
ENSP00000348965
ENST00000360184
Q14204 [Direct mapping]
Cytoplasmic dynein 1 heavy chain 1
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0007052 [mitotic spindle organization]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030175 [filopodium]
GO:0030286 [dynein complex]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0034063 [stress granule assembly]
GO:0044822 [poly(A) RNA binding]
GO:0051293 [establishment of spindle localization]
GO:0051959 [dynein light intermediate chain binding]
GO:0070062 [extracellular exosome]
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 4646 aa
532.4 kDa 		No 0
DYNC1H1-008
ENSP00000450674
ENST00000553423
H0YJ21 [Direct mapping]
Cytoplasmic dynein 1 heavy chain 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
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 180 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.