Expression of SLC22A4 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 22 (organic cation/zwitterion transporter), member 4

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

CAB015468

GENE INFORMATION
Gene name	SLC22A4 (HGNC Symbol)
Synonyms	MGC34546, OCTN1
Description	Solute carrier family 22 (organic cation/zwitterion transporter), member 4 (HGNC Symbol)
Entrez gene summary	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	132294443 - 132344206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197208 (version 83.38)
Entrez gene	6583
UniProt	Q9H015 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H015
Antibodypedia	SLC22A4 antibodies

PROTEIN BROWSER

SLC22A4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A4-001 ENSP00000200652 ENST00000200652	Q9H015 [Direct mapping] Solute carrier family 22 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006641 [triglyceride metabolic process] GO:0006814 [sodium ion transport] GO:0007589 [body fluid secretion] GO:0008513 [secondary active organic cation transmembrane transporter activity] GO:0009437 [carnitine metabolic process] GO:0015075 [ion transmembrane transporter activity] GO:0015226 [carnitine transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015491 [cation:cation antiporter activity] GO:0015651 [quaternary ammonium group transmembrane transporter activity] GO:0015695 [organic cation transport] GO:0015697 [quaternary ammonium group transport] GO:0015879 [carnitine transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0072337 [modified amino acid transport] GO:1902603 [carnitine transmembrane transport] Show all	551 aa 62.2 kDa	No	>9