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SLC22A4

GENERAL INFORMATION

Gene name

 SLC22A4

Gene description

 Solute carrier family 22 (organic cation/zwitterion transporter), member 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (fallopian tube)
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in subsets of immune cells in lymphoid and peripheral tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
CAB015468
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 SLC22A4 (HGNC Symbol)

Synonyms

 MGC34546, OCTN1

Description

 Solute carrier family 22 (organic cation/zwitterion transporter), member 4 (HGNC Symbol)

Entrez gene summary

 Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 132294443 - 132344206

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197208 (version 83.38)

Entrez gene

 6583

UniProt

 Q9H015 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H015

Antibodypedia

 SLC22A4 antibodies

PROTEIN BROWSER
SLC22A4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A4-001
ENSP00000200652
ENST00000200652
Q9H015 [Direct mapping]
Solute carrier family 22 member 4
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006641 [triglyceride metabolic process]
GO:0006814 [sodium ion transport]
GO:0007589 [body fluid secretion]
GO:0008513 [secondary active organic cation transmembrane transporter activity]
GO:0009437 [carnitine metabolic process]
GO:0015075 [ion transmembrane transporter activity]
GO:0015226 [carnitine transmembrane transporter activity]
GO:0015293 [symporter activity]
GO:0015491 [cation:cation antiporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015697 [quaternary ammonium group transport]
GO:0015879 [carnitine transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0072337 [modified amino acid transport]
GO:1902603 [carnitine transmembrane transport]
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 551 aa
62.2 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.