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Most cancer cells showed weak to moderate nuclear and/or granular cytoplasmic immunoreactivity. A few cases of hepatocellular carcinomas and pancreatic cancers were strongly stained.
Several prostate cancers, liver cancers few colorectal, breast, urothelial, renal and pancreatic cancers displayed moderate cytoplasmic positivity with additional membranous staining in few cases. Remaining cancer cells were weakly stained negative.
GENE INFORMATION
Gene name
CYP2B6 (HGNC Symbol)
Synonyms
CPB6, CYP2B, CYPIIB6
Description
Cytochrome P450, family 2, subfamily B, polypeptide 6 (HGNC Symbol)
Entrez gene summary
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
