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CYP2B6

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GENERAL INFORMATION

Gene name

 CYP2B6

Gene description

 Cytochrome P450, family 2, subfamily B, polypeptide 6

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear membrane. In addition localized to the cytosol & nucleoplasm.

RNA cell category

 Cell line enhanced (HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear membrane (approved)

Additional location

 In addition localized to the Nucleoplasm (uncertain), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA062973
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear membrane. In addition localized to the cytosol & nucleoplasm.

Main location

 Nuclear membrane (approved)

Additional location

 Nucleoplasm (uncertain), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA062973 CACO-2 Nucleoplasm
Nuclear membrane
HPA062973 HaCaT Nuclear membrane
Cytosol
HPA062973 U-2 OS Nucleoplasm
Nuclear membrane

GENE INFORMATION

Gene name

 CYP2B6 (HGNC Symbol)

Synonyms

 CPB6, CYP2B, CYPIIB6

Description

 Cytochrome P450, family 2, subfamily B, polypeptide 6 (HGNC Symbol)

Entrez gene summary

 This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 40991299 - 41018398

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197408 (version 83.38)

Entrez gene

 1555

UniProt

 P20813 (UniProt - Evidence at protein level)

neXtProt

 NX_P20813

Antibodypedia

 CYP2B6 antibodies

PROTEIN BROWSER
CYP2B6-001
CYP2B6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP2B6-001
ENSP00000324648
ENST00000324071
P20813 [Direct mapping]
Cytochrome P450 2B6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0008395 [steroid hydroxylase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0017144 [drug metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0042180 [cellular ketone metabolic process]
GO:0042738 [exogenous drug catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 491 aa
56.3 kDa 		Yes 0
CYP2B6-002
ENSP00000470582
ENST00000593831
M0QZJ2 [Direct mapping]
Cytochrome P450 2B6
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0008395 [steroid hydroxylase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 255 aa
29.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.