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SLC28A3

GENERAL INFORMATION

Gene name

 SLC28A3

Gene description

 Solute carrier family 28 (concentrative nucleoside transporter), member 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder, breast, skin)
GTEx:Tissue enhanced (salivary gland, skin)
FANTOM5:Group enriched (seminal vesicle, pancreas, gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression mainly in glandular cells in several tissues, including breast.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA023311 , HPA024729
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, breast, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (seminal vesicle, pancreas, gallbladder)

GENE INFORMATION

Gene name

 SLC28A3 (HGNC Symbol)

Synonyms

 CNT3

Description

 Solute carrier family 28 (concentrative nucleoside transporter), member 3 (HGNC Symbol)

Entrez gene summary

 Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

Chromosome location (bp)

 84275457 - 84340683

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197506 (version 83.38)

Entrez gene

 64078

UniProt

 Q9HAS3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAS3

Antibodypedia

 SLC28A3 antibodies

PROTEIN BROWSER
SLC28A3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC28A3-001
ENSP00000365413
ENST00000376238
Q9HAS3 [Direct mapping]
Solute carrier family 28 member 3
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
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GO:0001895 [retina homeostasis]
GO:0005415 [nucleoside:sodium symporter activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006863 [purine nucleobase transport]
GO:0015389 [pyrimidine- and adenine-specific:sodium symporter activity]
GO:0015390 [purine-specific nucleoside:sodium symporter activity]
GO:0015855 [pyrimidine nucleobase transport]
GO:0015860 [purine nucleoside transmembrane transport]
GO:0015864 [pyrimidine nucleoside transport]
GO:0016020 [membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0072531 [pyrimidine-containing compound transmembrane transport]
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 691 aa
76.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.