Expression of MFAP5 in cancer - Summary

CANCER ATLAS

Gene description

Microfibrillar associated protein 5

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA010553

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cancer cells were negative. Stromal cells were distinctly stained in most cases.

GENE INFORMATION
Gene name	MFAP5 (HGNC Symbol)
Synonyms	MAGP2, MP25
Description	Microfibrillar associated protein 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8637346 - 8662888
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197614 (version 83.38)
Entrez gene	8076
UniProt	Q13361 (UniProt - Evidence at protein level)
neXtProt	NX_Q13361
Antibodypedia	MFAP5 antibodies

PROTEIN BROWSER

MFAP5-001	MFAP5-002	MFAP5-003	MFAP5-007	MFAP5-010	MFAP5-012	MFAP5-015	MFAP5-016	MFAP5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFAP5-001 ENSP00000352455 ENST00000359478	Q13361 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0030198 [extracellular matrix organization] GO:0043206 [extracellular fibril organization] GO:0060216 [definitive hemopoiesis] Show all	173 aa 19.6 kDa	Yes	0
MFAP5-002 ENSP00000411997 ENST00000433590	B3KW70 [Direct mapping] Microfibrillar-associated protein 5; cDNA FLJ42377 fis, clone UTERU2035469, highly similar to Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	148 aa 17.1 kDa	Yes	0
MFAP5-003 ENSP00000379798 ENST00000396549	Q13361 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] GO:0060216 [definitive hemopoiesis] Show all	163 aa 18.6 kDa	Yes	0
MFAP5-007 ENSP00000438525 ENST00000535336	F5H413 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	109 aa 12 kDa	Yes	0
MFAP5-010 ENSP00000441492 ENST00000543369	F5GYX4 [Direct mapping] Microfibrillar-associated protein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	151 aa 17.3 kDa	Yes	0
MFAP5-012 ENSP00000445799 ENST00000544889	F5H1C0 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	91 aa 9.8 kDa	Yes	0
MFAP5-015 ENSP00000441185 ENST00000535411	H0YG03 [Direct mapping] Microfibrillar-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	163 aa 18.4 kDa	No	0
MFAP5-016 ENSP00000444531 ENST00000543467	H0YGS3 [Direct mapping] Microfibrillar-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	79 aa 9.4 kDa	No	0
MFAP5-201 ENSP00000440496 ENST00000540087	Q13361 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] GO:0060216 [definitive hemopoiesis] Show all	163 aa 18.6 kDa	Yes	0