Tissue expression of MFAP5 - Summary - The Human Protein Atlas

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MFAP5

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MFAP5
Gene description	Microfibrillar associated protein 5
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Tissue enhanced (endometrium)
FANTOM5:	Tissue enhanced (placenta, endometrium)

Protein evidence

Evidence at protein level

Protein expression

Distinct stromal and extracellular matrix expression in all tissues.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA010553
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta, endometrium)

GENE INFORMATION
Gene name	MFAP5 (HGNC Symbol)
Synonyms	MAGP2, MP25
Description	Microfibrillar associated protein 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8637346 - 8662888
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197614 (version 83.38)
Entrez gene	8076
UniProt	Q13361 (UniProt - Evidence at protein level)
neXtProt	NX_Q13361
Antibodypedia	MFAP5 antibodies

PROTEIN BROWSER

MFAP5-001	MFAP5-002	MFAP5-003	MFAP5-007	MFAP5-010	MFAP5-012	MFAP5-015	MFAP5-016	MFAP5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFAP5-001 ENSP00000352455 ENST00000359478	Q13361 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0030198 [extracellular matrix organization] GO:0043206 [extracellular fibril organization] GO:0060216 [definitive hemopoiesis] Show all	173 aa 19.6 kDa	Yes	0
MFAP5-002 ENSP00000411997 ENST00000433590	B3KW70 [Direct mapping] Microfibrillar-associated protein 5; cDNA FLJ42377 fis, clone UTERU2035469, highly similar to Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	148 aa 17.1 kDa	Yes	0
MFAP5-003 ENSP00000379798 ENST00000396549	Q13361 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] GO:0060216 [definitive hemopoiesis] Show all	163 aa 18.6 kDa	Yes	0
MFAP5-007 ENSP00000438525 ENST00000535336	F5H413 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	109 aa 12 kDa	Yes	0
MFAP5-010 ENSP00000441492 ENST00000543369	F5GYX4 [Direct mapping] Microfibrillar-associated protein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	151 aa 17.3 kDa	Yes	0
MFAP5-012 ENSP00000445799 ENST00000544889	F5H1C0 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	91 aa 9.8 kDa	Yes	0
MFAP5-015 ENSP00000441185 ENST00000535411	H0YG03 [Direct mapping] Microfibrillar-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	163 aa 18.4 kDa	No	0
MFAP5-016 ENSP00000444531 ENST00000543467	H0YGS3 [Direct mapping] Microfibrillar-associated protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] Show all	79 aa 9.4 kDa	No	0
MFAP5-201 ENSP00000440496 ENST00000540087	Q13361 [Direct mapping] Microfibrillar-associated protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] GO:0060216 [definitive hemopoiesis] Show all	163 aa 18.6 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.