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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

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MYH6
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MYH6

Gene description

Myosin, heavy chain 6, cardiac muscle, alpha

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (heart muscle)
GTEx:Tissue enriched (heart muscle)
FANTOM5:Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in heart and skeletal muscle.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA001239 , HPA001349 , CAB075723 , CAB075724 , CAB075725
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION

Gene name

MYH6

Synonyms

Description

Myosin, heavy chain 6, cardiac muscle, alpha (HGNC Symbol)

Entrez gene summary

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Mar 2010]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

23381990 - 23408277

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197616 (version 83.38)

Entrez gene

4624

UniProt

P13533 (UniProt - Evidence at protein level)

neXtProt

NX_P13533

Antibodypedia

MYH6 antibodies

PROTEIN BROWSER

MYH6-001
MYH6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH6-001
ENSP00000348634
ENST00000356287
P13533 [Direct mapping]
Myosin-6
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001701 [in utero embryonic development]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0007522 [visceral muscle development]
GO:0008016 [regulation of heart contraction]
GO:0008217 [regulation of blood pressure]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0019901 [protein kinase binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030239 [myofibril assembly]
GO:0030898 [actin-dependent ATPase activity]
GO:0032982 [myosin filament]
GO:0043462 [regulation of ATPase activity]
GO:0045214 [sarcomere organization]
GO:0046034 [ATP metabolic process]
GO:0048739 [cardiac muscle fiber development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
1939 aa
223.7 kDa
No 0
MYH6-201
ENSP00000386041
ENST00000405093
P13533 [Direct mapping]
Myosin-6
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001701 [in utero embryonic development]
GO:0001725 [stress fiber]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0007522 [visceral muscle development]
GO:0008016 [regulation of heart contraction]
GO:0008217 [regulation of blood pressure]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0019901 [protein kinase binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030018 [Z disc]
GO:0030048 [actin filament-based movement]
GO:0030049 [muscle filament sliding]
GO:0030239 [myofibril assembly]
GO:0030509 [BMP signaling pathway]
GO:0030898 [actin-dependent ATPase activity]
GO:0032982 [myosin filament]
GO:0043462 [regulation of ATPase activity]
GO:0045214 [sarcomere organization]
GO:0046034 [ATP metabolic process]
GO:0048739 [cardiac muscle fiber development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060420 [regulation of heart growth]
Show all
1939 aa
223.7 kDa
No 0

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