Cell atlas - SERPINB13 - The Human Protein Atlas

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SERPINB13

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SERPINB13
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 13
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nuclear speckles.
RNA cell category	Group enriched (HaCaT, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (uncertain), Cytosol (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052630
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HaCaT, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nuclear speckles.

Main location

Nuclear speckles (uncertain), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052630	HaCaT	Nuclear speckles
	HPA052630	HaCaT	Cytosol
	HPA052630	RT4	Nuclear speckles
	HPA052630	RT4	Cytosol
	HPA052630	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	SERPINB13 (HGNC Symbol)
Synonyms	headpin, HUR7, hurpin, PI13
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 13 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.33
Chromosome location (bp)	63586989 - 63604639
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197641 (version 83.38)
Entrez gene	5275
UniProt	Q9UIV8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIV8
Antibodypedia	SERPINB13 antibodies

PROTEIN BROWSER

SERPINB13-001	SERPINB13-004	SERPINB13-005	SERPINB13-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB13-001 ENSP00000341584 ENST00000344731	Q9UIV8 [Direct mapping] Serpin B13 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0009411 [response to UV] GO:0010951 [negative regulation of endopeptidase activity] GO:0030162 [regulation of proteolysis] GO:0070062 [extracellular exosome] GO:1902173 [negative regulation of keratinocyte apoptotic process] Show all	391 aa 44.3 kDa	No	0
SERPINB13-004 ENSP00000391156 ENST00000415733	H7BZS9 [Direct mapping] Serpin B13 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0016021 [integral component of membrane] Show all	124 aa 13.7 kDa	No	0
SERPINB13-005 ENSP00000388300 ENST00000431153	C9JL93 [Direct mapping] Serpin B13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	158 aa 17.9 kDa	No	1
SERPINB13-201 ENSP00000269489 ENST00000269489	A0A0A0MQW3 [Direct mapping] Serpin B13 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	400 aa 45.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.