Tissue expression of SERPINB13 - Summary - The Human Protein Atlas

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SERPINB13

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SERPINB13
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 13
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (esophagus)
GTEx:	Tissue enhanced (esophagus, vagina)
FANTOM5:	Group enriched (tonsil, esophagus, cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in squamous epithelia.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA057129
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (esophagus)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, vagina)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (tonsil, esophagus, cervix, uterine)

GENE INFORMATION
Gene name	SERPINB13 (HGNC Symbol)
Synonyms	headpin, HUR7, hurpin, PI13
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 13 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.33
Chromosome location (bp)	63586989 - 63604639
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197641 (version 83.38)
Entrez gene	5275
UniProt	Q9UIV8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIV8
Antibodypedia	SERPINB13 antibodies

PROTEIN BROWSER

SERPINB13-001	SERPINB13-004	SERPINB13-005	SERPINB13-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB13-001 ENSP00000341584 ENST00000344731	Q9UIV8 [Direct mapping] Serpin B13 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0009411 [response to UV] GO:0010951 [negative regulation of endopeptidase activity] GO:0030162 [regulation of proteolysis] GO:0070062 [extracellular exosome] GO:1902173 [negative regulation of keratinocyte apoptotic process] Show all	391 aa 44.3 kDa	No	0
SERPINB13-004 ENSP00000391156 ENST00000415733	H7BZS9 [Direct mapping] Serpin B13 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0016021 [integral component of membrane] Show all	124 aa 13.7 kDa	No	0
SERPINB13-005 ENSP00000388300 ENST00000431153	C9JL93 [Direct mapping] Serpin B13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	158 aa 17.9 kDa	No	1
SERPINB13-201 ENSP00000269489 ENST00000269489	A0A0A0MQW3 [Direct mapping] Serpin B13 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	400 aa 45.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.