Expression of LHFPL5 in cancer - Summary

CANCER ATLAS

Gene description

Lipoma HMGIC fusion partner-like 5

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA055110

GENE INFORMATION
Gene name	LHFPL5 (HGNC Symbol)
Synonyms	DFNB67, dJ510O8.8, MGC33835, Tmhs
Description	Lipoma HMGIC fusion partner-like 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	35805293 - 35833874
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197753 (version 83.38)
Entrez gene	222662
UniProt	Q8TAF8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAF8
Antibodypedia	LHFPL5 antibodies

PROTEIN BROWSER

LHFPL5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHFPL5-002 ENSP00000353346 ENST00000360215	Q8TAF8 [Direct mapping] Tetraspan membrane protein of hair cell stereocilia Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007605 [sensory perception of sound] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0032421 [stereocilium bundle] GO:0032426 [stereocilium bundle tip] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0060088 [auditory receptor cell stereocilium organization] Show all	219 aa 24.2 kDa	No	4