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OCLN

CANCER ATLAS

Gene description

 Occludin

Protein class

 Disease related genes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005933
CAB013075
CAB068212
CAB068213
CAB068214

GENE INFORMATION

Gene name

 OCLN (HGNC Symbol)

Synonyms

 PPP1R115

Description

 Occludin (HGNC Symbol)

Entrez gene summary

 This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 69492292 - 69558104

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197822 (version 83.38)

Entrez gene

 100506658

UniProt

 Q16625 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16625

Antibodypedia

 OCLN antibodies

PROTEIN BROWSER
OCLN-001
OCLN-002
OCLN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OCLN-001
ENSP00000347379
ENST00000355237
Q16625 [Direct mapping]
Occludin
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008119 [thiopurine S-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030139 [endocytic vesicle]
GO:0031410 [cytoplasmic vesicle]
GO:0032259 [methylation]
GO:0045216 [cell-cell junction organization]
GO:0046498 [S-adenosylhomocysteine metabolic process]
GO:0046500 [S-adenosylmethionine metabolic process]
GO:0070830 [bicellular tight junction assembly]
Show all
 522 aa
59.1 kDa 		No 4
OCLN-002
ENSP00000379719
ENST00000396442
Q16625 [Direct mapping]
Occludin
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
Show all
 522 aa
59.1 kDa 		No 4
OCLN-201
ENSP00000445940
ENST00000538151
Q16625 [Direct mapping]
Occludin
Show all
Transporters
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0016021 [integral component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
Show all
 271 aa
31.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.