Cell atlas - OCLN - The Human Protein Atlas

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OCLN

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	OCLN
Gene description	Occludin
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cell junctions.
RNA cell category	Cell line enhanced (CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA005933
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cell junctions.

Main location

Plasma membrane (supported), Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005933	A-431	Plasma membrane
	HPA005933	A-431	Cell Junctions
	HPA005933	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	OCLN (HGNC Symbol)
Synonyms	PPP1R115
Description	Occludin (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
Chromosome	5
Cytoband	q13.2
Chromosome location (bp)	69492292 - 69558104
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197822 (version 83.38)
Entrez gene	100506658
UniProt	Q16625 (UniProt - Evidence at protein level)
neXtProt	NX_Q16625
Antibodypedia	OCLN antibodies

PROTEIN BROWSER

OCLN-001	OCLN-002	OCLN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OCLN-001 ENSP00000347379 ENST00000355237	Q16625 [Direct mapping] Occludin Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008119 [thiopurine S-methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0030139 [endocytic vesicle] GO:0031410 [cytoplasmic vesicle] GO:0032259 [methylation] GO:0045216 [cell-cell junction organization] GO:0046498 [S-adenosylhomocysteine metabolic process] GO:0046500 [S-adenosylmethionine metabolic process] GO:0070830 [bicellular tight junction assembly] Show all	522 aa 59.1 kDa	No	4
OCLN-002 ENSP00000379719 ENST00000396442	Q16625 [Direct mapping] Occludin Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	522 aa 59.1 kDa	No	4
OCLN-201 ENSP00000445940 ENST00000538151	Q16625 [Direct mapping] Occludin Show all	Transporters MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005923 [bicellular tight junction] GO:0006461 [protein complex assembly] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0012501 [programmed cell death] GO:0016021 [integral component of membrane] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	271 aa 31.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.