Cell atlas - ADAMTSL2 - The Human Protein Atlas

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ADAMTSL2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ADAMTSL2
Gene description	ADAMTS-like 2
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (SH-SY5Y, RPMI-8226, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053812
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, RPMI-8226, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053812	Hep G2	Nucleoplasm
	HPA053812	Hep G2	Vesicles
	HPA053812	SH-SY5Y	No staining

GENE INFORMATION
Gene name	ADAMTSL2 (HGNC Symbol)
Synonyms	KIAA0605
Description	ADAMTS-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	133532164 - 133575519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197859 (version 83.38)
Entrez gene	9719
UniProt	Q86TH1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TH1
Antibodypedia	ADAMTSL2 antibodies

PROTEIN BROWSER

ADAMTSL2-001	ADAMTSL2-002	ADAMTSL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTSL2-001 ENSP00000346478 ENST00000354484	Q86TH1 [Direct mapping] ADAMTS-like protein 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0030198 [extracellular matrix organization] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031012 [extracellular matrix] GO:0050436 [microfibril binding] GO:0060481 [lobar bronchus epithelium development] Show all	951 aa 104.6 kDa	Yes	0
ADAMTSL2-002 ENSP00000376781 ENST00000393061	B1B0D4 [Direct mapping] ADAMTS-like protein 2 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1060 aa 116.3 kDa	No	0
ADAMTSL2-201 ENSP00000376780 ENST00000393060	Q86TH1 [Direct mapping] ADAMTS-like protein 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031012 [extracellular matrix] Show all	951 aa 104.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.