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ADAMTSL2

GENERAL INFORMATION

Gene name

 ADAMTSL2

Gene description

 ADAMTS-like 2

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland)
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissue types, including adrenal gland and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA045634 , HPA053812
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ADAMTSL2 (HGNC Symbol)

Synonyms

 KIAA0605

Description

 ADAMTS-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009]

Chromosome

 9

Cytoband

 q34.2

Chromosome location (bp)

 133532164 - 133575519

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197859 (version 83.38)

Entrez gene

 9719

UniProt

 Q86TH1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86TH1

Antibodypedia

 ADAMTSL2 antibodies

PROTEIN BROWSER
ADAMTSL2-001
ADAMTSL2-002
ADAMTSL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTSL2-001
ENSP00000346478
ENST00000354484
Q86TH1 [Direct mapping]
ADAMTS-like protein 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0030198 [extracellular matrix organization]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031012 [extracellular matrix]
GO:0050436 [microfibril binding]
GO:0060481 [lobar bronchus epithelium development]
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 951 aa
104.6 kDa 		Yes 0
ADAMTSL2-002
ENSP00000376781
ENST00000393061
B1B0D4 [Direct mapping]
ADAMTS-like protein 2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
 1060 aa
116.3 kDa 		No 0
ADAMTSL2-201
ENSP00000376780
ENST00000393060
Q86TH1 [Direct mapping]
ADAMTS-like protein 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031012 [extracellular matrix]
Show all
 951 aa
104.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.