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MYO1C

GENERAL INFORMATION

Gene name

 MYO1C

Gene description

 Myosin IC

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001768 , CAB037023
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MYO1C (HGNC Symbol)

Synonyms

 myr2

Description

 Myosin IC (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1464098 - 1492812

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197879 (version 83.38)

Entrez gene

 4641

UniProt

 O00159 (UniProt - Evidence at protein level)

neXtProt

 NX_O00159

Antibodypedia

 MYO1C antibodies

PROTEIN BROWSER
«
MYO1C-001
MYO1C-002
MYO1C-003
MYO1C-005
MYO1C-006
MYO1C-007
MYO1C-008
MYO1C-009
MYO1C-010
MYO1C-011
MYO1C-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO1C-001
ENSP00000352834
ENST00000359786
O00159 [Direct mapping]
Unconventional myosin-Ic
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0006605 [protein targeting]
GO:0006612 [protein targeting to membrane]
GO:0006810 [transport]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0009925 [basal plasma membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0017160 [Ral GTPase binding]
GO:0030335 [positive regulation of cell migration]
GO:0030898 [actin-dependent ATPase activity]
GO:0031941 [filamentous actin]
GO:0032420 [stereocilium]
GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045160 [myosin I complex]
GO:0051028 [mRNA transport]
GO:0060171 [stereocilium membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
 1063 aa
121.7 kDa 		No 0
MYO1C-002
ENSP00000459174
ENST00000575158
O00159 [Direct mapping]
Unconventional myosin-Ic
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006605 [protein targeting]
GO:0006612 [protein targeting to membrane]
GO:0008152 [metabolic process]
GO:0009925 [basal plasma membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0017160 [Ral GTPase binding]
GO:0030335 [positive regulation of cell migration]
GO:0031941 [filamentous actin]
GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0051028 [mRNA transport]
GO:0060171 [stereocilium membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
 1028 aa
117.9 kDa 		No 0
MYO1C-003
ENSP00000437685
ENST00000545534
F5H6E2 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 1039 aa
119 kDa 		No 0
MYO1C-005
ENSP00000461175
ENST00000574790
I3L4D4 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 164 aa
18.7 kDa 		No 0
MYO1C-006
ENSP00000460415
ENST00000575335
I3L3F5 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 138 aa
15.9 kDa 		No 0
MYO1C-007
ENSP00000459271
ENST00000570984
I3L204 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 267 aa
30.7 kDa 		No 0
MYO1C-008
ENSP00000458610
ENST00000571715
I3L168 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 134 aa
15.4 kDa 		No 0
MYO1C-009
ENSP00000460831
ENST00000573853
I3L3Y6 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 170 aa
19.5 kDa 		No 0
MYO1C-010
ENSP00000412197
ENST00000438665
O00159 [Direct mapping]
Unconventional myosin-Ic
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006605 [protein targeting]
GO:0006612 [protein targeting to membrane]
GO:0008152 [metabolic process]
GO:0009925 [basal plasma membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0017160 [Ral GTPase binding]
GO:0030335 [positive regulation of cell migration]
GO:0031941 [filamentous actin]
GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0051028 [mRNA transport]
GO:0060171 [stereocilium membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
 1044 aa
119.6 kDa 		No 0
MYO1C-011
ENSP00000461682
ENST00000570490
I3L501 [Direct mapping]
Unconventional myosin-Ic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 169 aa
19.2 kDa 		No 0
MYO1C-201
ENSP00000354283
ENST00000361007
O00159 [Direct mapping]
Unconventional myosin-Ic
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006605 [protein targeting]
GO:0006612 [protein targeting to membrane]
GO:0008152 [metabolic process]
GO:0009925 [basal plasma membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0017160 [Ral GTPase binding]
GO:0030335 [positive regulation of cell migration]
GO:0031941 [filamentous actin]
GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0051028 [mRNA transport]
GO:0060171 [stereocilium membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
 1028 aa
117.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.