Expression of ADH5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Alcohol dehydrogenase 5 (class III), chi polypeptide

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044578	HPA061919

GENE INFORMATION
Gene name	ADH5 (HGNC Symbol)
Synonyms	ADH-3, ADHX, FDH
Description	Alcohol dehydrogenase 5 (class III), chi polypeptide (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99070978 - 99088801
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197894 (version 83.38)
Entrez gene	128
UniProt	P11766 (UniProt - Evidence at protein level)
neXtProt	NX_P11766
Antibodypedia	ADH5 antibodies

PROTEIN BROWSER

ADH5-001	ADH5-011	ADH5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADH5-001 ENSP00000296412 ENST00000296412	P11766 [Direct mapping] Alcohol dehydrogenase class-3 Q6IRT1 [Target identity:100%; Query identity:100%] S-(hydroxymethyl)glutathione dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0003016 [respiratory system process] GO:0004022 [alcohol dehydrogenase (NAD) activity] GO:0005504 [fatty acid binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006805 [xenobiotic metabolic process] GO:0008270 [zinc ion binding] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0018119 [peptidyl-cysteine S-nitrosylation] GO:0018467 [formaldehyde dehydrogenase activity] GO:0032496 [response to lipopolysaccharide] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045777 [positive regulation of blood pressure] GO:0046294 [formaldehyde catabolic process] GO:0051409 [response to nitrosative stress] GO:0051775 [response to redox state] GO:0051903 [S-(hydroxymethyl)glutathione dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	374 aa 39.7 kDa	No	0
ADH5-011 ENSP00000427049 ENST00000503130	H0YAG8 [Direct mapping] Alcohol dehydrogenase class-3 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	262 aa 27.5 kDa	No	0
ADH5-201 ENSP00000487496 ENST00000626055	D6RAY0 [Direct mapping] Alcohol dehydrogenase class-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.1 kDa	No	0