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ADH5

GENERAL INFORMATION

Gene name

 ADH5

Gene description

 Alcohol dehydrogenase 5 (class III), chi polypeptide

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA044578 , HPA061919
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ADH5 (HGNC Symbol)

Synonyms

 ADH-3, ADHX, FDH

Description

 Alcohol dehydrogenase 5 (class III), chi polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99070978 - 99088801

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197894 (version 83.38)

Entrez gene

 128

UniProt

 P11766 (UniProt - Evidence at protein level)

neXtProt

 NX_P11766

Antibodypedia

 ADH5 antibodies

PROTEIN BROWSER
ADH5-001
ADH5-011
ADH5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH5-001
ENSP00000296412
ENST00000296412
P11766 [Direct mapping]
Alcohol dehydrogenase class-3
Q6IRT1 [Target identity:100%; Query identity:100%]
S-(hydroxymethyl)glutathione dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003016 [respiratory system process]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0005504 [fatty acid binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0018467 [formaldehyde dehydrogenase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045777 [positive regulation of blood pressure]
GO:0046294 [formaldehyde catabolic process]
GO:0051409 [response to nitrosative stress]
GO:0051775 [response to redox state]
GO:0051903 [S-(hydroxymethyl)glutathione dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 374 aa
39.7 kDa 		No 0
ADH5-011
ENSP00000427049
ENST00000503130
H0YAG8 [Direct mapping]
Alcohol dehydrogenase class-3
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 262 aa
27.5 kDa 		No 0
ADH5-201
ENSP00000487496
ENST00000626055
D6RAY0 [Direct mapping]
Alcohol dehydrogenase class-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 56 aa
6.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.