Expression of TEAD4 in cancer - Summary

CANCER ATLAS

Gene description

TEA domain family member 4

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA056896

GENE INFORMATION
Gene name	TEAD4 (HGNC Symbol)
Synonyms	EFTR-2, RTEF-1, TCF13L1, TEF-3, TEFR-1
Description	TEA domain family member 4 (HGNC Symbol)
Entrez gene summary	This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	2959330 - 3040673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197905 (version 83.38)
Entrez gene	7004
UniProt	Q15561 (UniProt - Evidence at protein level)
neXtProt	NX_Q15561
Antibodypedia	TEAD4 antibodies

PROTEIN BROWSER

TEAD4-001	TEAD4-002	TEAD4-003	TEAD4-004	TEAD4-005	TEAD4-006	TEAD4-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TEAD4-001 ENSP00000352926 ENST00000359864	Q53GI4 [Direct mapping] TEA domain family member 4 isoform 1 variant; Transcriptional enhancer factor TEF-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0035329 [hippo signaling] Show all	434 aa 48.3 kDa	No	0
TEAD4-002 ENSP00000351184 ENST00000358409	A0A0A0MRF3 [Direct mapping] Transcriptional enhancer factor TEF-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0035329 [hippo signaling] Show all	391 aa 44 kDa	No	0
TEAD4-003 ENSP00000380311 ENST00000397122	Q15561 [Direct mapping] Transcriptional enhancer factor TEF-3 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007517 [muscle organ development] GO:0010467 [gene expression] GO:0035329 [hippo signaling] Show all	305 aa 34.2 kDa	No	0
TEAD4-004 ENSP00000438960 ENST00000540314	H0YFK0 [Direct mapping] Transcriptional enhancer factor TEF-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.2 kDa	No	0
TEAD4-005 ENSP00000444528 ENST00000543035	H0YGS2 [Direct mapping] Transcriptional enhancer factor TEF-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	175 aa 18.7 kDa	No	0
TEAD4-006 ENSP00000438453 ENST00000536826	H0YFF9 [Direct mapping] Transcriptional enhancer factor TEF-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	72 aa 7.5 kDa	No	0
TEAD4-008 ENSP00000441959 ENST00000544666	H0YG62 [Direct mapping] Transcriptional enhancer factor TEF-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	189 aa 20.1 kDa	No	0