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TEAD4

GENERAL INFORMATION

Gene name

 TEAD4

Gene description

 TEA domain family member 4

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA056896
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Vagina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TEAD4 (HGNC Symbol)

Synonyms

 EFTR-2, RTEF-1, TCF13L1, TEF-3, TEFR-1

Description

 TEA domain family member 4 (HGNC Symbol)

Entrez gene summary

 This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 2959330 - 3040673

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197905 (version 83.38)

Entrez gene

 7004

UniProt

 Q15561 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15561

Antibodypedia

 TEAD4 antibodies

PROTEIN BROWSER
TEAD4-001
TEAD4-002
TEAD4-003
TEAD4-004
TEAD4-005
TEAD4-006
TEAD4-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TEAD4-001
ENSP00000352926
ENST00000359864
Q53GI4 [Direct mapping]
TEA domain family member 4 isoform 1 variant; Transcriptional enhancer factor TEF-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0035329 [hippo signaling]
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 434 aa
48.3 kDa 		No 0
TEAD4-002
ENSP00000351184
ENST00000358409
A0A0A0MRF3 [Direct mapping]
Transcriptional enhancer factor TEF-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0035329 [hippo signaling]
Show all
 391 aa
44 kDa 		No 0
TEAD4-003
ENSP00000380311
ENST00000397122
Q15561 [Direct mapping]
Transcriptional enhancer factor TEF-3
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007517 [muscle organ development]
GO:0010467 [gene expression]
GO:0035329 [hippo signaling]
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 305 aa
34.2 kDa 		No 0
TEAD4-004
ENSP00000438960
ENST00000540314
H0YFK0 [Direct mapping]
Transcriptional enhancer factor TEF-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 22 aa
2.2 kDa 		No 0
TEAD4-005
ENSP00000444528
ENST00000543035
H0YGS2 [Direct mapping]
Transcriptional enhancer factor TEF-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 175 aa
18.7 kDa 		No 0
TEAD4-006
ENSP00000438453
ENST00000536826
H0YFF9 [Direct mapping]
Transcriptional enhancer factor TEF-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 72 aa
7.5 kDa 		No 0
TEAD4-008
ENSP00000441959
ENST00000544666
H0YG62 [Direct mapping]
Transcriptional enhancer factor TEF-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 189 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.