Expression of IFNA1 in cancer - Summary

CANCER ATLAS

Gene description

Interferon, alpha 1

Protein class

Cancer-related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047557

GENE INFORMATION
Gene name	IFNA1 (HGNC Symbol)
Synonyms	IFL, IFN, IFN-ALPHA, IFN-alphaD, IFNA13, IFNA@
Description	Interferon, alpha 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]
Chromosome	9
Cytoband	p21.3
Chromosome location (bp)	21409169 - 21441316
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197919 (version 83.38)
Entrez gene	3439
UniProt	P01562 (UniProt - Evidence at protein level)
neXtProt	NX_P01562
Antibodypedia	IFNA1 antibodies

PROTEIN BROWSER

IFNA1-001	IFNA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFNA1-001 ENSP00000276927 ENST00000276927	P01562 [Direct mapping] Interferon alpha-1/13 L0N195 [Target identity:100%; Query identity:100%] Interferon-alpha1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002250 [adaptive immune response] GO:0002286 [T cell activation involved in immune response] GO:0002323 [natural killer cell activation involved in immune response] GO:0005125 [cytokine activity] GO:0005126 [cytokine receptor binding] GO:0005132 [type I interferon receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006952 [defense response] GO:0006959 [humoral immune response] GO:0007596 [blood coagulation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030183 [B cell differentiation] GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein] GO:0042100 [B cell proliferation] GO:0043330 [response to exogenous dsRNA] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] Show all	189 aa 21.7 kDa	Yes	0
IFNA1-201 ENSP00000485003 ENST00000613815	A0A087X2I3 [Direct mapping] Interferon alpha-1/13 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002250 [adaptive immune response] GO:0002286 [T cell activation involved in immune response] GO:0002323 [natural killer cell activation involved in immune response] GO:0005125 [cytokine activity] GO:0005126 [cytokine receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006952 [defense response] GO:0006959 [humoral immune response] GO:0019221 [cytokine-mediated signaling pathway] GO:0030183 [B cell differentiation] GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein] GO:0042100 [B cell proliferation] GO:0043330 [response to exogenous dsRNA] GO:0051607 [defense response to virus] Show all	189 aa 22.1 kDa	Yes	0