Tissue expression of TUBA3C - Summary - The Human Protein Atlas

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TUBA3C

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TUBA3C
Gene description	Tubulin, alpha 3c
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA039247 , HPA043684 , HPA063394
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	TUBA3C (HGNC Symbol)
Synonyms	bA408E5.3, TUBA2
Description	Tubulin, alpha 3c (HGNC Symbol)
Entrez gene summary	Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	19173770 - 19181852
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198033 (version 83.38)
Entrez gene	7278
UniProt	Q13748 (UniProt - Evidence at protein level)
neXtProt	NX_Q13748
Antibodypedia	TUBA3C antibodies

PROTEIN BROWSER

TUBA3C-002	TUBA3C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUBA3C-002 ENSP00000382982 ENST00000400113	Q13748 [Direct mapping] Tubulin alpha-3C/D chain Q1ZYQ1 [Target identity:100%; Query identity:100%] Tubulin, alpha 2; Tubulin, alpha 2, isoform CRA_b; cDNA FLJ77591, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007017 [microtubule-based process] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] Show all	450 aa 50 kDa	No	0
TUBA3C-201 ENSP00000482878 ENST00000618094	Q13748 [Direct mapping] Tubulin alpha-3C/D chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007017 [microtubule-based process] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] Show all	418 aa 46.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.