Tissue expression of GRK6 - Summary - The Human Protein Atlas

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GRK6

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GRK6
Gene description	G protein-coupled receptor kinase 6
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression, most abundant in subsets of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA015327 , HPA018903
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GRK6 (HGNC Symbol)
Synonyms	GPRK6
Description	G protein-coupled receptor kinase 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	177403204 - 177442901
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198055 (version 83.38)
Entrez gene	2870
UniProt	P43250 (UniProt - Evidence at protein level)
neXtProt	NX_P43250
Antibodypedia	GRK6 antibodies

PROTEIN BROWSER

GRK6-001	GRK6-003	GRK6-004	GRK6-005	GRK6-006	GRK6-008	GRK6-009	GRK6-010	GRK6-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRK6-001 ENSP00000347655 ENST00000355472	P43250 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0047696 [beta-adrenergic receptor kinase activity] Show all	576 aa 66 kDa	No	0
GRK6-003 ENSP00000427581 ENST00000507633	D6RHX8 [Direct mapping] G protein-coupled receptor kinase 6 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] Show all	475 aa 54.5 kDa	No	0
GRK6-004 ENSP00000348230 ENST00000355958	P43250 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0047696 [beta-adrenergic receptor kinase activity] Show all	560 aa 64.3 kDa	No	0
GRK6-005 ENSP00000425391 ENST00000511244	D6RDA3 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 15 kDa	No	0
GRK6-006 ENSP00000422342 ENST00000512684	D6RC88 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 2 kDa	No	0
GRK6-008 ENSP00000421055 ENST00000506296	D6RHC7 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] Show all	253 aa 29.4 kDa	No	0
GRK6-009 ENSP00000422873 ENST00000502598	D6R9V4 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.4 kDa	No	0
GRK6-010 ENSP00000433511 ENST00000528793	P43250 [Direct mapping] G protein-coupled receptor kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0010360 [negative regulation of anion channel activity] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0047696 [beta-adrenergic receptor kinase activity] Show all	589 aa 67.3 kDa	No	0
GRK6-011 ENSP00000377204 ENST00000393576	F8W9W2 [Direct mapping] G protein-coupled receptor kinase 6 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] Show all	542 aa 62.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.