Expression of AKR1B10 in cancer - Summary

CANCER ATLAS

Gene description

Aldo-keto reductase family 1, member B10 (aldose reductase)

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA020280	CAB070163

GENE INFORMATION
Gene name	AKR1B10 (HGNC Symbol)
Synonyms	AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
Description	Aldo-keto reductase family 1, member B10 (aldose reductase) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q33
Chromosome location (bp)	134527592 - 134541408
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198074 (version 83.38)
Entrez gene	57016
UniProt	O60218 (UniProt - Evidence at protein level)
neXtProt	NX_O60218
Antibodypedia	AKR1B10 antibodies

PROTEIN BROWSER

AKR1B10-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKR1B10-001 ENSP00000352584 ENST00000359579	O60218 [Direct mapping] Aldo-keto reductase family 1 member B10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001758 [retinal dehydrogenase activity] GO:0004033 [aldo-keto reductase (NADP) activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006081 [cellular aldehyde metabolic process] GO:0007586 [digestion] GO:0007603 [phototransduction, visible light] GO:0008202 [steroid metabolic process] GO:0016488 [farnesol catabolic process] GO:0016491 [oxidoreductase activity] GO:0044597 [daunorubicin metabolic process] GO:0044598 [doxorubicin metabolic process] GO:0045550 [geranylgeranyl reductase activity] GO:0047718 [indanol dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	316 aa 36 kDa	No	0