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AKR1B10

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GENERAL INFORMATION

Gene name

 AKR1B10

Gene description

 Aldo-keto reductase family 1, member B10 (aldose reductase)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Group enriched (A549, Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Plasma membrane (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA020280 , HPA073633
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (A549, Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Cytosol (supported)

Additional location

 Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA020280 A549 Plasma membrane
Cytosol
HPA020280 Hep G2 Cytosol Intensity
HPA020280 U-2 OS No staining    
HPA073633 A549 Plasma membrane
Cytosol Intensity
HPA073633 Hep G2 Aggresome
Cytosol Intensity

GENE INFORMATION

Gene name

 AKR1B10 (HGNC Symbol)

Synonyms

 AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI

Description

 Aldo-keto reductase family 1, member B10 (aldose reductase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 134527592 - 134541408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198074 (version 83.38)

Entrez gene

 57016

UniProt

 O60218 (UniProt - Evidence at protein level)

neXtProt

 NX_O60218

Antibodypedia

 AKR1B10 antibodies

PROTEIN BROWSER
AKR1B10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1B10-001
ENSP00000352584
ENST00000359579
O60218 [Direct mapping]
Aldo-keto reductase family 1 member B10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001758 [retinal dehydrogenase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006081 [cellular aldehyde metabolic process]
GO:0007586 [digestion]
GO:0007603 [phototransduction, visible light]
GO:0008202 [steroid metabolic process]
GO:0016488 [farnesol catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0045550 [geranylgeranyl reductase activity]
GO:0047718 [indanol dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 316 aa
36 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.