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ADH4

CANCER ATLAS

Gene description

 Alcohol dehydrogenase 4 (class II), pi polypeptide

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020525

GENE INFORMATION

Gene name

 ADH4 (HGNC Symbol)

Synonyms

 ADH-2

Description

 Alcohol dehydrogenase 4 (class II), pi polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99123657 - 99157792

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198099 (version 83.38)

Entrez gene

 127

UniProt

 P08319 (UniProt - Evidence at protein level)

neXtProt

 NX_P08319

Antibodypedia

 ADH4 antibodies

PROTEIN BROWSER
ADH4-001
ADH4-002
ADH4-005
ADH4-006
ADH4-011
ADH4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH4-001
ENSP00000265512
ENST00000265512
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
 380 aa
40.2 kDa 		No 0
ADH4-002
ENSP00000424630
ENST00000508393
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006067 [ethanol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
 399 aa
42.6 kDa 		No 0
ADH4-005
ENSP00000425416
ENST00000505590
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
 399 aa
42.6 kDa 		No 0
ADH4-006
ENSP00000427525
ENST00000504125
D6RIB1 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
 206 aa
21.5 kDa 		No 0
ADH4-011
ENSP00000423571
ENST00000512499
D6R9K8 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
 257 aa
27.4 kDa 		No 0
ADH4-201
ENSP00000486450
ENST00000629236
A0A0D9SFB5 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
 391 aa
41.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.