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ADH4

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GENERAL INFORMATION

Gene name

 ADH4

Gene description

 Alcohol dehydrogenase 4 (class II), pi polypeptide

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & cytosol.

RNA cell category

 Cell line enriched (Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (uncertain), Cytosol (uncertain)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA020525
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & cytosol.

Main location

 Nucleus (uncertain), Cytosol (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA020525 Hep G2 Nucleus Spatial
Cytosol Spatial

GENE INFORMATION

Gene name

 ADH4 (HGNC Symbol)

Synonyms

 ADH-2

Description

 Alcohol dehydrogenase 4 (class II), pi polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99123657 - 99157792

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198099 (version 83.38)

Entrez gene

 127

UniProt

 P08319 (UniProt - Evidence at protein level)

neXtProt

 NX_P08319

Antibodypedia

 ADH4 antibodies

PROTEIN BROWSER
ADH4-001
ADH4-002
ADH4-005
ADH4-006
ADH4-011
ADH4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH4-001
ENSP00000265512
ENST00000265512
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
 380 aa
40.2 kDa 		No 0
ADH4-002
ENSP00000424630
ENST00000508393
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006067 [ethanol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
 399 aa
42.6 kDa 		No 0
ADH4-005
ENSP00000425416
ENST00000505590
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
 399 aa
42.6 kDa 		No 0
ADH4-006
ENSP00000427525
ENST00000504125
D6RIB1 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
 206 aa
21.5 kDa 		No 0
ADH4-011
ENSP00000423571
ENST00000512499
D6R9K8 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
 257 aa
27.4 kDa 		No 0
ADH4-201
ENSP00000486450
ENST00000629236
A0A0D9SFB5 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
 391 aa
41.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.