Cell atlas - GPN1 - The Human Protein Atlas

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GPN1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoplasm

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GPN1
Gene description	GPN-loop GTPase 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Cytosol (supported)
Additional location	In addition localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036793
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the mitochondria.

Main location

Nucleoplasm (supported), Cytosol (supported)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036793	A-431	Nucleoplasm
			Mitochondria
			Cytosol
	HPA036793	U-2 OS	Nucleoplasm
	HPA036793	U-2 OS	Cytosol
	HPA036793	U-251 MG	Nucleoplasm
	HPA036793	U-251 MG	Cytosol

GENE INFORMATION
Gene name	GPN1 (HGNC Symbol)
Synonyms	ATPBD1A, MBDIN, NTPBP, RPAP4, XAB1
Description	GPN-loop GTPase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27628247 - 27651508
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198522 (version 83.38)
Entrez gene	11321
UniProt	Q9HCN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCN4
Antibodypedia	GPN1 antibodies

PROTEIN BROWSER

GPN1-001	GPN1-003	GPN1-008	GPN1-009	GPN1-010	GPN1-201	GPN1-202	GPN1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPN1-001 ENSP00000264718 ENST00000264718	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	388 aa 43.3 kDa	No	0
GPN1-003 ENSP00000384255 ENST00000407583	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	362 aa 41 kDa	No	0
GPN1-008 ENSP00000427269 ENST00000503738	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	279 aa 31.8 kDa	No	0
GPN1-009 ENSP00000424678 ENST00000515877	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	295 aa 33.5 kDa	No	0
GPN1-010 ENSP00000476446 ENST00000610189	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Q53RZ9 [Target identity:100%; Query identity:100%] Putative uncharacterized protein MBDin; XPA binding protein 1, GTPase, isoform CRA_b; cDNA, FLJ93453, Homo sapiens XPA binding protein 1 (XAB1), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	374 aa 41.7 kDa	No	0
GPN1-201 ENSP00000398115 ENST00000424214	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	295 aa 33.5 kDa	No	0
GPN1-202 ENSP00000412170 ENST00000458167	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	279 aa 31.8 kDa	No	0
GPN1-203 ENSP00000484680 ENST00000616939	Q9HCN4 [Direct mapping] GPN-loop GTPase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	388 aa 43.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.