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A majority of malignancies showed weak to moderate cytoplasmic immunoreactivity. Renal and testicular cancers were generally negative. Strong dot-like staining pattern was observed in rare cases of example stomach and breast cancer.
This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]