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Most cancer tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in several cases. Several gliomas, papillary adenocarcinomas of thyroid, squamous cell carcinomas of head and neck region exhibited strong immunoreactivity.
Most cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in a few cases. A few cases of prostate adenocarcinomas exhibited strong immunoreactivity. Carcinoids along with several urothelial, renal and endometrial cancers were negative.
GENE INFORMATION
Gene name
STK39 (HGNC Symbol)
Synonyms
DCHT, SPAK
Description
Serine threonine kinase 39 (HGNC Symbol)
Entrez gene summary
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Q9UEW8 [Direct mapping] STE20/SPS1-related proline-alanine-rich protein kinase
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007346 [regulation of mitotic cell cycle] GO:0008217 [regulation of blood pressure] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0043268 [positive regulation of potassium ion transport] GO:0050727 [regulation of inflammatory response] GO:0071476 [cellular hypotonic response] GO:0090188 [negative regulation of pancreatic juice secretion] GO:1901017 [negative regulation of potassium ion transmembrane transporter activity] GO:1901380 [negative regulation of potassium ion transmembrane transport] GO:2000021 [regulation of ion homeostasis] GO:2000681 [negative regulation of rubidium ion transport] GO:2000687 [negative regulation of rubidium ion transmembrane transporter activity]
