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This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Q9UEW8 [Direct mapping] STE20/SPS1-related proline-alanine-rich protein kinase
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007346 [regulation of mitotic cell cycle] GO:0008217 [regulation of blood pressure] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0043268 [positive regulation of potassium ion transport] GO:0050727 [regulation of inflammatory response] GO:0071476 [cellular hypotonic response] GO:0090188 [negative regulation of pancreatic juice secretion] GO:1901017 [negative regulation of potassium ion transmembrane transporter activity] GO:1901380 [negative regulation of potassium ion transmembrane transport] GO:2000021 [regulation of ion homeostasis] GO:2000681 [negative regulation of rubidium ion transport] GO:2000687 [negative regulation of rubidium ion transmembrane transporter activity]
