Cell atlas - TUSC1 - The Human Protein Atlas

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TUSC1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	TUSC1
Gene description	Tumor suppressor candidate 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051426
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleus.

Main location

Vesicles (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051426	HeLa	Nucleus
	HPA051426	HeLa	Vesicles
	HPA051426	SH-SY5Y	Vesicles
	HPA051426	U-2 OS	Vesicles

GENE INFORMATION
Gene name	TUSC1 (HGNC Symbol)
Synonyms	TSG-9
Description	Tumor suppressor candidate 1 (HGNC Symbol)
Entrez gene summary	This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p21.2
Chromosome location (bp)	25676389 - 25678440
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198680 (version 83.38)
Entrez gene	286319
UniProt	Q2TAM9 (UniProt - Evidence at protein level)
neXtProt	NX_Q2TAM9
Antibodypedia	TUSC1 antibodies

PROTEIN BROWSER

TUSC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUSC1-001 ENSP00000350716 ENST00000358022	Q2TAM9 [Direct mapping] Tumor suppressor candidate gene 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		212 aa 23.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.