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ECI2

CANCER ATLAS

Gene description

 Enoyl-CoA delta isomerase 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022130
HPA031626

GENE INFORMATION

Gene name

 ECI2 (HGNC Symbol)

Synonyms

 ACBD2, DRS1, HCA88, PECI

Description

 Enoyl-CoA delta isomerase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 4115689 - 4135597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198721 (version 83.38)

Entrez gene

 10455

UniProt

 O75521 (UniProt - Evidence at protein level)

neXtProt

 NX_O75521

Antibodypedia

 ECI2 antibodies

PROTEIN BROWSER
ECI2-001
ECI2-003
ECI2-005
ECI2-006
ECI2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ECI2-001
ENSP00000369468
ENST00000380125
A0A0C4DGA2 [Direct mapping]
Enoyl-CoA delta isomerase 2, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 364 aa
40.2 kDa 		No 0
ECI2-003
ENSP00000369461
ENST00000380118
O75521 [Direct mapping]
Enoyl-CoA delta isomerase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003824 [catalytic activity]
GO:0004165 [dodecenoyl-CoA delta-isomerase activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009062 [fatty acid catabolic process]
GO:0016020 [membrane]
GO:0016863 [intramolecular oxidoreductase activity, transposing C=C bonds]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 394 aa
43.6 kDa 		No 0
ECI2-005
ENSP00000420309
ENST00000465828
A0A0C4DGA2 [Direct mapping]
Enoyl-CoA delta isomerase 2, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 364 aa
40.2 kDa 		No 0
ECI2-006
ENSP00000354737
ENST00000361538
A0A0C4DGA2 [Direct mapping]
Enoyl-CoA delta isomerase 2, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 364 aa
40.2 kDa 		No 0
ECI2-009
ENSP00000417459
ENST00000495548
C9JB63 [Direct mapping]
Enoyl-CoA delta isomerase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
Show all
 220 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.