Cell atlas - ECI2 - The Human Protein Atlas

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ECI2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Peroxisomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	ECI2
Gene description	Enoyl-CoA delta isomerase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the peroxisome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Peroxisomes (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA022130 , HPA031626
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the peroxisome.

Main location

Peroxisomes (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA022130	A-431	No staining
	HPA022130	U-2 OS	Vesicles
	HPA022130	U-2 OS	Mitochondria
	HPA022130	U-251 MG	Vesicles	Intensity
	HPA031626	Hep G2	Peroxisomes
	HPA031626	U-251 MG	Nucleoplasm
	HPA031626	U-251 MG	Peroxisomes

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA031626	U-2 OS	Image	ECI2 localizes to peroxisomes, as it partially co-localizes with the peroxisomal marker ABCD3.

GENE INFORMATION
Gene name	ECI2 (HGNC Symbol)
Synonyms	ACBD2, DRS1, HCA88, PECI
Description	Enoyl-CoA delta isomerase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	4115689 - 4135597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198721 (version 83.38)
Entrez gene	10455
UniProt	O75521 (UniProt - Evidence at protein level)
neXtProt	NX_O75521
Antibodypedia	ECI2 antibodies

PROTEIN BROWSER

ECI2-001	ECI2-003	ECI2-005	ECI2-006	ECI2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECI2-001 ENSP00000369468 ENST00000380125	A0A0C4DGA2 [Direct mapping] Enoyl-CoA delta isomerase 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	364 aa 40.2 kDa	No	0
ECI2-003 ENSP00000369461 ENST00000380118	O75521 [Direct mapping] Enoyl-CoA delta isomerase 2, mitochondrial Show all	Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003824 [catalytic activity] GO:0004165 [dodecenoyl-CoA delta-isomerase activity] GO:0005102 [receptor binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009062 [fatty acid catabolic process] GO:0016020 [membrane] GO:0016863 [intramolecular oxidoreductase activity, transposing C=C bonds] GO:0043231 [intracellular membrane-bounded organelle] Show all	394 aa 43.6 kDa	No	0
ECI2-005 ENSP00000420309 ENST00000465828	A0A0C4DGA2 [Direct mapping] Enoyl-CoA delta isomerase 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	364 aa 40.2 kDa	No	0
ECI2-006 ENSP00000354737 ENST00000361538	A0A0C4DGA2 [Direct mapping] Enoyl-CoA delta isomerase 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	364 aa 40.2 kDa	No	0
ECI2-009 ENSP00000417459 ENST00000495548	C9JB63 [Direct mapping] Enoyl-CoA delta isomerase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] Show all	220 aa 24 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.