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EGFL6

CANCER ATLAS

Gene description

 EGF-like-domain, multiple 6

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA001838

GENE INFORMATION

Gene name

 EGFL6 (HGNC Symbol)

Synonyms

 MAEG

Description

 EGF-like-domain, multiple 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 13569605 - 13633575

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000198759 (version 83.38)

Entrez gene

 25975

UniProt

 Q8IUX8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IUX8

Antibodypedia

 EGFL6 antibodies

PROTEIN BROWSER
EGFL6-002
EGFL6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGFL6-002
ENSP00000355126
ENST00000361306
Q8IUX8 [Direct mapping]
Epidermal growth factor-like protein 6
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organismal development]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0033631 [cell-cell adhesion mediated by integrin]
Show all
 553 aa
61.3 kDa 		Yes 0
EGFL6-003
ENSP00000369976
ENST00000380602
Q8IUX8 [Direct mapping]
Epidermal growth factor-like protein 6
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organismal development]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0033631 [cell-cell adhesion mediated by integrin]
Show all
 554 aa
61.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.