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EGFL6

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GENERAL INFORMATION

Gene name

 EGFL6

Gene description

 EGF-like-domain, multiple 6

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (BJ hTERT+, NTERA-2)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BJ hTERT+, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 EGFL6 (HGNC Symbol)

Synonyms

 MAEG

Description

 EGF-like-domain, multiple 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 13569605 - 13633575

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000198759 (version 83.38)

Entrez gene

 25975

UniProt

 Q8IUX8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IUX8

Antibodypedia

 EGFL6 antibodies

PROTEIN BROWSER
EGFL6-002
EGFL6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGFL6-002
ENSP00000355126
ENST00000361306
Q8IUX8 [Direct mapping]
Epidermal growth factor-like protein 6
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organismal development]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0033631 [cell-cell adhesion mediated by integrin]
Show all
 553 aa
61.3 kDa 		Yes 0
EGFL6-003
ENSP00000369976
ENST00000380602
Q8IUX8 [Direct mapping]
Epidermal growth factor-like protein 6
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organismal development]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0033631 [cell-cell adhesion mediated by integrin]
Show all
 554 aa
61.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.