Expression of LTN1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Listerin E3 ubiquitin protein ligase 1

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA029143	CAB034164

GENE INFORMATION
Gene name	LTN1 (HGNC Symbol)
Synonyms	C21orf10, C21orf98, FLJ11053, KIAA0714, LISTERIN, RNF160, ZNF294
Description	Listerin E3 ubiquitin protein ligase 1 (HGNC Symbol)
Entrez gene summary	Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	28928144 - 28992956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198862 (version 83.38)
Entrez gene	26046
UniProt	O94822 (UniProt - Evidence at protein level)
neXtProt	NX_O94822
Antibodypedia	LTN1 antibodies

PROTEIN BROWSER

LTN1-001	LTN1-002	LTN1-008	LTN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTN1-001 ENSP00000373846 ENST00000389194	O94822 [Direct mapping] E3 ubiquitin-protein ligase listerin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] Show all	1812 aa 205.2 kDa	No	1
LTN1-002 ENSP00000373847 ENST00000389195	H7BYG8 [Direct mapping] E3 ubiquitin-protein ligase listerin Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	813 aa 91.4 kDa	No	0
LTN1-008 ENSP00000354977 ENST00000361371	O94822 [Direct mapping] E3 ubiquitin-protein ligase listerin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] Show all	1766 aa 200.6 kDa	No	1
LTN1-201 ENSP00000478783 ENST00000614971	O94822 [Direct mapping] E3 ubiquitin-protein ligase listerin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	1812 aa 205.2 kDa	No	0