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LTN1

GENERAL INFORMATION

Gene name

 LTN1

Gene description

 Listerin E3 ubiquitin protein ligase 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA029143 , CAB034164
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LTN1 (HGNC Symbol)

Synonyms

 C21orf10, C21orf98, FLJ11053, KIAA0714, LISTERIN, RNF160, ZNF294

Description

 Listerin E3 ubiquitin protein ligase 1 (HGNC Symbol)

Entrez gene summary

 Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 28928144 - 28992956

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198862 (version 83.38)

Entrez gene

 26046

UniProt

 O94822 (UniProt - Evidence at protein level)

neXtProt

 NX_O94822

Antibodypedia

 LTN1 antibodies

PROTEIN BROWSER
LTN1-001
LTN1-002
LTN1-008
LTN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LTN1-001
ENSP00000373846
ENST00000389194
O94822 [Direct mapping]
E3 ubiquitin-protein ligase listerin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
Show all
 1812 aa
205.2 kDa 		No 1
LTN1-002
ENSP00000373847
ENST00000389195
H7BYG8 [Direct mapping]
E3 ubiquitin-protein ligase listerin
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 813 aa
91.4 kDa 		No 0
LTN1-008
ENSP00000354977
ENST00000361371
O94822 [Direct mapping]
E3 ubiquitin-protein ligase listerin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
Show all
 1766 aa
200.6 kDa 		No 1
LTN1-201
ENSP00000478783
ENST00000614971
O94822 [Direct mapping]
E3 ubiquitin-protein ligase listerin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 1812 aa
205.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.