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POU3F3

GENERAL INFORMATION

Gene name

 POU3F3

Gene description

 POU class 3 homeobox 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, epididymis, kidney, seminal vesicle)
GTEx:Group enriched (kidney, hippocampus, caudate, cerebral cortex, hypothalamus, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in kidney and cytoplasmic expression in processes in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA067151
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, epididymis, kidney, seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, hippocampus, caudate, cerebral cortex, hypothalamus, cerebellum)

GENE INFORMATION

Gene name

 POU3F3 (HGNC Symbol)

Synonyms

 BRN1, OTF8

Description

 POU class 3 homeobox 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]

Chromosome

 2

Cytoband

 q12.1

Chromosome location (bp)

 104855511 - 104860471

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198914 (version 83.38)

Entrez gene

 5455

UniProt

 P20264 (UniProt - Evidence at transcript level)

neXtProt

 NX_P20264

Antibodypedia

 POU3F3 antibodies

PROTEIN BROWSER
POU3F3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU3F3-001
ENSP00000355001
ENST00000361360
P20264 [Direct mapping]
POU domain, class 3, transcription factor 3
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001822 [kidney development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021869 [forebrain ventricular zone progenitor cell division]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071837 [HMG box domain binding]
GO:0072218 [metanephric ascending thin limb development]
GO:0072227 [metanephric macula densa development]
GO:0072233 [metanephric thick ascending limb development]
GO:0072236 [metanephric loop of Henle development]
GO:0072240 [metanephric DCT cell differentiation]
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 500 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.