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RORB

CANCER ATLAS

Gene description

 RAR-related orphan receptor B

Protein class

 Nuclear receptors, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008393

GENE INFORMATION

Gene name

 RORB (HGNC Symbol)

Synonyms

 NR1F2, ROR-BETA, RZRB

Description

 RAR-related orphan receptor B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

Chromosome

 9

Cytoband

 q21.13

Chromosome location (bp)

 74497365 - 74693177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198963 (version 83.38)

Entrez gene

 6096

UniProt

 Q92753 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92753

Antibodypedia

 RORB antibodies

PROTEIN BROWSER
RORB-001
RORB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RORB-001
ENSP00000366093
ENST00000376896
Q92753 [Direct mapping]
Nuclear receptor ROR-beta
Q58EY0 [Target identity:100%; Query identity:100%]
RAR-related orphan receptor B; RAR-related orphan receptor beta; cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007420 [brain development]
GO:0007601 [visual perception]
GO:0007623 [circadian rhythm]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008502 [melatonin receptor activity]
GO:0009725 [response to hormone]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035881 [amacrine cell differentiation]
GO:0042462 [eye photoreceptor cell development]
GO:0042752 [regulation of circadian rhythm]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0048511 [rhythmic process]
GO:0060041 [retina development in camera-type eye]
GO:0071300 [cellular response to retinoic acid]
Show all
 459 aa
52.1 kDa 		No 0
RORB-201
ENSP00000379507
ENST00000396204
Q92753 [Direct mapping]
Nuclear receptor ROR-beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035881 [amacrine cell differentiation]
GO:0042462 [eye photoreceptor cell development]
GO:0042752 [regulation of circadian rhythm]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0048511 [rhythmic process]
GO:0060041 [retina development in camera-type eye]
GO:0071300 [cellular response to retinoic acid]
Show all
 470 aa
53.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.