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RORB

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GENERAL INFORMATION

Gene name

 RORB

Gene description

 RAR-related orphan receptor B

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Cell line enhanced (SH-SY5Y, MOLT-4)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA008393
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, MOLT-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA008393 SH-SY5Y Nucleus
HPA008393 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 RORB (HGNC Symbol)

Synonyms

 NR1F2, ROR-BETA, RZRB

Description

 RAR-related orphan receptor B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

Chromosome

 9

Cytoband

 q21.13

Chromosome location (bp)

 74497365 - 74693177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198963 (version 83.38)

Entrez gene

 6096

UniProt

 Q92753 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92753

Antibodypedia

 RORB antibodies

PROTEIN BROWSER
RORB-001
RORB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RORB-001
ENSP00000366093
ENST00000376896
Q92753 [Direct mapping]
Nuclear receptor ROR-beta
Q58EY0 [Target identity:100%; Query identity:100%]
RAR-related orphan receptor B; RAR-related orphan receptor beta; cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007420 [brain development]
GO:0007601 [visual perception]
GO:0007623 [circadian rhythm]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008502 [melatonin receptor activity]
GO:0009725 [response to hormone]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035881 [amacrine cell differentiation]
GO:0042462 [eye photoreceptor cell development]
GO:0042752 [regulation of circadian rhythm]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0048511 [rhythmic process]
GO:0060041 [retina development in camera-type eye]
GO:0071300 [cellular response to retinoic acid]
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 459 aa
52.1 kDa 		No 0
RORB-201
ENSP00000379507
ENST00000396204
Q92753 [Direct mapping]
Nuclear receptor ROR-beta
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035881 [amacrine cell differentiation]
GO:0042462 [eye photoreceptor cell development]
GO:0042752 [regulation of circadian rhythm]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0048511 [rhythmic process]
GO:0060041 [retina development in camera-type eye]
GO:0071300 [cellular response to retinoic acid]
Show all
 470 aa
53.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.