Tissue expression of FCGR3A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FCGR3A
Gene description	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Protein class	CD markers Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in a subset of cells including lung macrophages, Kupffer cells in liver and non-germinal center cells in lymph node.

DATA RELIABILITY
Data reliability description	External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA055431 , CAB032435
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)

GENE INFORMATION
Gene name	FCGR3A (HGNC Symbol)
Synonyms	CD16, CD16a, FCG3, FCGR3
Description	Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161541759 - 161550737
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203747 (version 83.38)
Entrez gene	2214
UniProt	P08637 (UniProt - Evidence at protein level)
neXtProt	NX_P08637
Antibodypedia	FCGR3A antibodies

PROTEIN BROWSER

FCGR3A-001	FCGR3A-003	FCGR3A-004	FCGR3A-005	FCGR3A-201	FCGR3A-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR3A-001 ENSP00000356946 ENST00000367969	M9MML0 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	290 aa 32.7 kDa	No	1
FCGR3A-003 ENSP00000356944 ENST00000367967	P08637 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-A Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0019864 [IgG binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	254 aa 29.1 kDa	Yes	1
FCGR3A-004 ENSP00000396567 ENST00000442336	C9JC71 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	105 aa 11.8 kDa	Yes	0
FCGR3A-005 ENSP00000410180 ENST00000426740	H0Y755 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	271 aa 30.7 kDa	No	1
FCGR3A-201 ENSP00000416607 ENST00000436743	P08637 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-A Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0019864 [IgG binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	254 aa 29.1 kDa	Yes	1
FCGR3A-202 ENSP00000392047 ENST00000443193	P08637 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-A Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0019864 [IgG binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	254 aa 29.1 kDa	Yes	1