Tissue expression of LIME1 - Summary - The Human Protein Atlas

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LIME1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LIME1
Gene description	Lck interacting transmembrane adaptor 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver, stomach)
FANTOM5:	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several cell types, mainly immune cells with distinct positivity in plasma.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. CAB015363
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)

GENE INFORMATION
Gene name	LIME1 (HGNC Symbol)
Synonyms	dJ583P15.4, FLJ20406, LIME
Description	Lck interacting transmembrane adaptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	63736283 - 63739103
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203896 (version 83.38)
Entrez gene	54923
UniProt	Q9H400 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H400
Antibodypedia	LIME1 antibodies

PROTEIN BROWSER

LIME1-001	LIME1-002	LIME1-004	LIME1-006	LIME1-008	LIME1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIME1-001 ENSP00000477561 ENST00000480139	A0A087WT39 [Direct mapping] Lck-interacting transmembrane adapter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] Show all	176 aa 18.1 kDa	Yes	0
LIME1-002 ENSP00000476772 ENST00000493265	V9GYI1 [Direct mapping] Lck-interacting transmembrane adapter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] Show all	131 aa 13.5 kDa	Yes	0
LIME1-004 ENSP00000478705 ENST00000476183	A0A087WUJ1 [Direct mapping] Lck-interacting transmembrane adapter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] Show all	253 aa 27.2 kDa	Yes	0
LIME1-006 ENSP00000309521 ENST00000309546	Q9H400 [Direct mapping] Lck-interacting transmembrane adapter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] Show all	295 aa 31.3 kDa	Yes	0
LIME1-008 ENSP00000414506 ENST00000444951	X6RKG5 [Direct mapping] Lck-interacting transmembrane adapter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] Show all	107 aa 11.9 kDa	Yes	0
LIME1-011 ENSP00000482812 ENST00000487026	A0A087WZP9 [Direct mapping] Lck-interacting transmembrane adapter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] Show all	211 aa 21.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.