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PHACTR4

CANCER ATLAS

Gene description

 Phosphatase and actin regulator 4

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028985

GENE INFORMATION

Gene name

 PHACTR4 (HGNC Symbol)

Synonyms

 FLJ13171, PPP1R124

Description

 Phosphatase and actin regulator 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 28369582 - 28500369

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204138 (version 83.38)

Entrez gene

 65979

UniProt

 Q8IZ21 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZ21

Antibodypedia

 PHACTR4 antibodies

PROTEIN BROWSER
PHACTR4-001
PHACTR4-004
PHACTR4-008
PHACTR4-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHACTR4-001
ENSP00000362945
ENST00000373839
Q8IZ21 [Direct mapping]
Phosphatase and actin regulator 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001755 [neural crest cell migration]
GO:0001843 [neural tube closure]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0008157 [protein phosphatase 1 binding]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0043085 [positive regulation of catalytic activity]
GO:0048484 [enteric nervous system development]
GO:0051726 [regulation of cell cycle]
GO:0061386 [closure of optic fissure]
GO:0071862 [protein phosphatase type 1 activator activity]
GO:2001045 [negative regulation of integrin-mediated signaling pathway]
Show all
 702 aa
78.2 kDa 		No 0
PHACTR4-004
ENSP00000362942
ENST00000373836
Q8IZ21 [Direct mapping]
Phosphatase and actin regulator 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001755 [neural crest cell migration]
GO:0001843 [neural tube closure]
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0008157 [protein phosphatase 1 binding]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0043085 [positive regulation of catalytic activity]
GO:0048484 [enteric nervous system development]
GO:0051726 [regulation of cell cycle]
GO:0061386 [closure of optic fissure]
GO:0071862 [protein phosphatase type 1 activator activity]
GO:2001045 [negative regulation of integrin-mediated signaling pathway]
Show all
 712 aa
79.1 kDa 		No 0
PHACTR4-008
ENSP00000487630
ENST00000632202
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 221 aa
24.1 kDa 		No 0
PHACTR4-009
ENSP00000488137
ENST00000633167
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 106 aa
12.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.