Cell atlas - PHACTR4 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PHACTR4
Gene description	Phosphatase and actin regulator 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Additional location	In addition localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028985
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the intermediate filaments.

Main location

Plasma membrane (approved), Cytosol (approved)

Additional location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA028985	A-431	Plasma membrane
HPA028985	A-431	Cytosol
HPA028985	U-2 OS	Plasma membrane
		Intermediate filaments
		Cytosol
HPA028985	U-251 MG	Plasma membrane
		Intermediate filaments
		Cytosol

GENE INFORMATION
Gene name	PHACTR4 (HGNC Symbol)
Synonyms	FLJ13171, PPP1R124
Description	Phosphatase and actin regulator 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p35.3
Chromosome location (bp)	28369582 - 28500369
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204138 (version 83.38)
Entrez gene	65979
UniProt	Q8IZ21 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZ21
Antibodypedia	PHACTR4 antibodies

PROTEIN BROWSER

PHACTR4-001	PHACTR4-004	PHACTR4-008	PHACTR4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHACTR4-001 ENSP00000362945 ENST00000373839	Q8IZ21 [Direct mapping] Phosphatase and actin regulator 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001755 [neural crest cell migration] GO:0001843 [neural tube closure] GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0008157 [protein phosphatase 1 binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0043085 [positive regulation of catalytic activity] GO:0048484 [enteric nervous system development] GO:0051726 [regulation of cell cycle] GO:0061386 [closure of optic fissure] GO:0071862 [protein phosphatase type 1 activator activity] GO:2001045 [negative regulation of integrin-mediated signaling pathway] Show all	702 aa 78.2 kDa	No	0
PHACTR4-004 ENSP00000362942 ENST00000373836	Q8IZ21 [Direct mapping] Phosphatase and actin regulator 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001755 [neural crest cell migration] GO:0001843 [neural tube closure] GO:0003779 [actin binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0008157 [protein phosphatase 1 binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0043085 [positive regulation of catalytic activity] GO:0048484 [enteric nervous system development] GO:0051726 [regulation of cell cycle] GO:0061386 [closure of optic fissure] GO:0071862 [protein phosphatase type 1 activator activity] GO:2001045 [negative regulation of integrin-mediated signaling pathway] Show all	712 aa 79.1 kDa	No	0
PHACTR4-008 ENSP00000487630 ENST00000632202		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 24.1 kDa	No	0
PHACTR4-009 ENSP00000488137 ENST00000633167		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 12.1 kDa	No	0