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BRD2

CANCER ATLAS

Gene description

 Bromodomain containing 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042816

GENE INFORMATION

Gene name

 BRD2 (HGNC Symbol)

Synonyms

 D6S113E, FSRG1, KIAA9001, NAT, RING3

Description

 Bromodomain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 6

Cytoband

 p21.32

Chromosome location (bp)

 32968660 - 32981505

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204256 (version 83.38)

Entrez gene

 6046

UniProt

 P25440 (UniProt - Evidence at protein level)

neXtProt

 NX_P25440

Antibodypedia

 BRD2 antibodies

PROTEIN BROWSER
BRD2-001
BRD2-002
BRD2-005
BRD2-006
BRD2-008
BRD2-009
BRD2-023
BRD2-026
BRD2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRD2-001
ENSP00000363958
ENST00000374825
P25440 [Direct mapping]
Bromodomain-containing protein 2
A0A024RCR5 [Target identity:100%; Query identity:100%]
Bromodomain containing 2, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0016568 [chromatin modification]
GO:0070577 [lysine-acetylated histone binding]
Show all
 801 aa
88.1 kDa 		No 0
BRD2-002
ENSP00000363964
ENST00000374831
P25440 [Direct mapping]
Bromodomain-containing protein 2
A0A024RCR5 [Target identity:100%; Query identity:100%]
Bromodomain containing 2, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0016568 [chromatin modification]
GO:0070577 [lysine-acetylated histone binding]
Show all
 801 aa
88.1 kDa 		No 0
BRD2-005
ENSP00000378702
ENST00000395287
P25440 [Direct mapping]
Bromodomain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0016568 [chromatin modification]
GO:0070577 [lysine-acetylated histone binding]
Show all
 836 aa
92 kDa 		No 0
BRD2-006
ENSP00000409613
ENST00000449025
H0Y6K2 [Direct mapping]
Bromodomain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 807 aa
88.3 kDa 		No 0
BRD2-008
ENSP00000464077
ENST00000496118
J3QR72 [Direct mapping]
Bromodomain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
17.5 kDa 		No 0
BRD2-009
ENSP00000411195
ENST00000456339
H0Y799 [Direct mapping]
Bromodomain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 296 aa
32.1 kDa 		No 0
BRD2-023
ENSP00000475691
ENST00000607833
U3KQA6 [Direct mapping]
Bromodomain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 552 aa
61.2 kDa 		No 0
BRD2-026
ENSP00000475288
ENST00000606059
U3KPW0 [Direct mapping]
Bromodomain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 159 aa
17.1 kDa 		No 0
BRD2-201
ENSP00000409145
ENST00000449085
P25440 [Direct mapping]
Bromodomain-containing protein 2
X5CF57 [Target identity:100%; Query identity:100%]
BRD2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0016568 [chromatin modification]
GO:0070577 [lysine-acetylated histone binding]
Show all
 754 aa
83.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.