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Colo-rectal and thyroid cancers and a few cases of endometrial and lung cancers exhibited moderate cytoplasmic immunoreactivity. Most other malignant tissues were weakly stained or negative.
Most of the malignant tissues were negative. Colo-rectal cancer showed mainly weak to moderate staining.
GENE INFORMATION
Gene name
COL15A1
Synonyms
Description
Collagen, type XV, alpha 1 (HGNC Symbol)
Entrez gene summary
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]