Cell atlas - COL15A1 - The Human Protein Atlas

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COL15A1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	COL15A1
Gene description	Collagen, type XV, alpha 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (BJ hTERT+, U-2197, WM-115, BJ, HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017913
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+, U-2197, WM-115, BJ, HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017913	BJ	Endoplasmic reticulum	Intensity

GENE INFORMATION
Gene name	COL15A1
Synonyms
Description	Collagen, type XV, alpha 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]
Chromosome	9
Cytoband	q22.33
Chromosome location (bp)	98943179 - 99070792
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204291 (version 83.38)
Entrez gene	1306
UniProt	P39059 (UniProt - Evidence at protein level)
neXtProt	NX_P39059
Antibodypedia	COL15A1 antibodies

PROTEIN BROWSER

COL15A1-001	COL15A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL15A1-001 ENSP00000364140 ENST00000375001	P39059 [Direct mapping] Collagen alpha-1(XV) chain Restin Restin-2 Restin-3 Restin-4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005198 [structural molecule activity] GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005582 [collagen type XV trimer] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0022617 [extracellular matrix disassembly] GO:0030154 [cell differentiation] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] Show all	1388 aa 141.7 kDa	Yes	0
COL15A1-201 ENSP00000483455 ENST00000610452	A0A087X0K0 [Direct mapping] Collagen alpha-1(XV) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0007155 [cell adhesion] GO:0031012 [extracellular matrix] Show all	1374 aa 140.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.