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LSM2

GENERAL INFORMATION

Gene name

 LSM2

Gene description

 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA066718
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0246810TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin051015202530RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina010203040506070Tags Per Million

GENE INFORMATION

Gene name

 LSM2 (HGNC Symbol)

Synonyms

 C6orf28, G7b, YBL026W

Description

 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31797396 - 31806984

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204392 (version 83.38)

Entrez gene

 57819

UniProt

 Q9Y333 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y333

Antibodypedia

 LSM2 antibodies

PROTEIN BROWSER
LSM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM2-001
ENSP00000364813
ENST00000375661
Q9Y333 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005688 [U6 snRNP]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0017070 [U6 snRNA binding]
GO:0017160 [Ral GTPase binding]
GO:0019901 [protein kinase binding]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:1990726 [Lsm1-7-Pat1 complex]
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 95 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.